Epistasis plays an important role in the genetic architecture of common human diseases and can be viewed from two perspectives, biological and statistical, each derived from and leading to different assumptions and research strategies. Biological epistasis is the result of physical interactions among biomolecules within gene regulatory networks and biochemical pathways in an individual such that the effect of a gene on a phenotype is dependent on one or more other genes. In contrast, statistical epistasis is defined as deviation from (...) additivity in a mathematical model summarizing the relationship between multilocus genotypes and phenotypic variation in a population. The goal of this essay is to review definitions and examples of biological and statistical epistasis and to explore the relationship between the two. Specifically, we present and discuss the following two questions in the context of human health and disease. First, when does statistical evidence of epistasis in human populations imply underlying biomolecular interactions in the etiology of disease? Second, when do biomolecular interactions produce patterns of statistical epistasis in human populations?Answers to these two reciprocal questions will provide an important framework for using genetic information to improve our ability to diagnose, prevent and treat common human diseases. We propose that systems biology will provide the necessary information for addressing these questions and that model systems such as bacteria, yeast and digital organisms will be a useful place to start. BioEssays 27:637–646, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

We are told that we live in a scientific world. All about us are the fruits of scientific research, and the products of scientific industry. But, in spite of this transformation of our material surroundings, scientific thought, or the scientific method as such, has had no effect upon the everyday thought and behaviour of our people. To be sure, along with the scientific gadgets a few scientific truths have been disseminated. They know the earth is round and moves about the (...) sun; they could know that bacteria cause disease and that they are themselves descended from less articulate forms of animal life. Even when such conclusions are accepted, it is on the basis of authority with no understanding as to how they arose and on what basis they stand. For the large majority, science has merely acquired a cloak of respectability; it is a stronger magic than that of our forebears, and our modern alchemy is known as a powerful though mysterious source of pecuniary profit. (shrink)

Religion is intrinsically social, and hence irretrievably organizational, although organization is often seen as the darker side of the religious experience--power, routinization, and bureaucracy. Religion and secular organizations have long received separate scholarly scrutiny, but until now their confluence has been little considered. This interdisciplinary collection of mostly unpublished papers is the first volume to remedy the deficit. The project grew out of a three-year inquiry into religious institutions undertaken by Yale University's Program on Non-Profit Organizations and sponsored by the (...) Lilly Endowment. The scholars who took part in this effort weree challenged to apply new perspectives to the study of religious organizations, especially that strand of contemporary secular organizational theory known as "New Institutionalism." The result was this groundbreaking volume, which includes papers on various aspects of such topics as the historical sources and patterns of U.S. religious organizations, contemporary patterns of denominational authority, the congregation as an organization, and the interface between religious and secular institutions and movements. The contributors include an interdisciplinary mix of scholars from economics, history, law, social administration, and sociology. (shrink)

In a philosophical approach to color, Gass explores man's perception of the color blue as well as its common erotic, symbolic, and emotional associations.

The concept of scientific history / Isaiah Berlin -- The limits of scientific history / W.H. Walsh -- The objectivity of history / J.A. Passmore -- Explanation in science and in history / C.G. Hempel -- The Popper-Hempel theory reconsidered / Alan Donagan -- The autonomy of historical understanding / Louis O. Mink -- Historical continuity and causal analysis / Michael Oakeshott -- Causal judgment in history and in the law / H.L.A. Hart and A.M. Honoré -- Causes, connections and (...) conditions in history / Michael Scriven -- The historical individual / A.C. Danto -- Methodological individualisms : definition and reduction / May Brodbeck -- Societal laws / Maurice Mandelbaum -- Determinism in history / Ernest Nagel. (shrink)

This update of the original version focuses on six central problems in the critical philosophy of history and explores the connections among them. Starting with the fundamentals of each philosophical topic in history and then delving into the specifics of each to better understand the surrounding issues, the reference first offers a comprehensive introduction into these topics then covers explanation and understanding ... objectivity and value judgment .. causes in history ... the nature and role of narrative ... and historical (...) determinism. Suitable for students, professors, and anyone else interested in the philosophy of history. (shrink)

Neurobiologist William Calvin explores the human brain, positing that the neurons in the brain operate in an accelerated version of biological evolution, evolving ideas through random variations and selections, and supports his hypothesis with numerous ca.

A systematic, rigorous, comprehensive, and unified overview of evolutionary game theory.

The pedagogical technique of the playful Plato, especially his ability to create living discourses that directly address the student, is the subject of Plato the Teacher. “The crisis of the Republic” refers to the decisive moment in his central dialogue when philosopher-readers realize that Plato’s is challenging them to choose justice by going back down into the dangerous Cave of political life for the sake of the greater Good, as both Socrates and Cicero did.

In this book, William H. F. Altman argues that it is not order of composition but reading order that makes Euthyphro, Apology of Socrates, Crito, and Phaedo “late dialogues,” and shows why Plato’s decision to interpolate the notoriously “late” Sophist and Statesman between Euthyphro and Apology deserves more respect from interpreters.

This book explains and defends a central ideas in the theory of history put forward by R. G. Collingwood, perhaps the foremost philosopher of history in the 20th century. Professor Dray analyses critically the idea of re-enactment, explores the limits of its applicability, and determines its relationship to other key Collingwoodian ideas, such as the role of imagination in historical thinking, and the indispensability of a point of view.

Combining engaging discussions and stimulating new case studies, BUSINESS ETHICS: A TEXTBOOK WITH CASES gives students a comprehensive survey of business ethics that will guide them toward becoming ethical professionals, even if they have never studied philosophy before. Rich with real-world examples, BUSINESS ETHICS: A TEXTBOOK WITH CASES invites students to critically analyze and apply a broad range of philosophical concepts and principles to today's most important issues in business and beyond. BUSINESS ETHICS: A TEXTBOOK WITH CASES is a concise (...) (without readings) and updated version of the eleventh edition of MORAL ISSUES IN BUSINESS. BUSINESS ETHICS: A TEXTBOOK WITH CASES is also available in an eBook format. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version. (shrink)

"[This] book guides readers in thinking deeply about important moral issues that frequently arise in business situations and helps them develop the reasoning and analytical skills to resolve those issues. Combining insightful and accessible textbook chapters by the authors, cases that highlight the real-world importance of key ethical concepts, and reading selections from the most influential voices in contemporary ethical debates, this book provides a comprehensive, flexible, and pedagogically proven course of study exploring the intersections of commerce and ethics."--Book cover.

Aimed at undergraduates, _Contemporary Ethics_ presupposes little or no familiarity with ethics and is written in a clear and engaging style. It provides students with a sympathetic but critical guide to utilitarianism, explaining its different forms and exploring the debates it has spawned. The book leads students through a number of current issues in contemporary ethics that are connected to controversies over and within utilitarianism. At the same time, it uses utilitarianism to introduce students to ethics as a subject. In (...) these ways, the book is not only a guide to utilitarianism, but also an introduction to some standard problems of ethics and to several important topics in contemporary ethical theory. (shrink)

In this book, William H. F. Altman considers the pedagogical connections behind the post-Republic dialogues from Timaeus to Theaetetus in the context of their Reading Order.

This book deals with theoretical problems that arise at points of contact between the concerns of philosophers and historians about the practice of ...

The German Stranger provides a guide to Leo Strauss that situates his thought in the context of National Socialism; by destroying any middle ground between 'Athens' and 'Jerusalem, ' Strauss undermined modernity's secular bulwark against political theology. Once National Socialism is understood as an atheistic religion re-enacted by post-Revelation 'philosophers, ' the German avatar of Plato's Athenian Stranger can be recognized as its principal theoreticia.